Effects of Treatment Interruption Patterns on Treatment Success Among Patients With Multidrug-Resistant Tuberculosis in Armenia and Abkhazia

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Effects of treatment interruption patterns on treatment success among patients with multidrug-resistant tuberculosis in Armenia and Abkhazia.

BACKGROUND The success of the current treatment regimen for multidrug-resistant (MDR) tuberculosis is poor partly owing to a high default rate. Many studies have explored predictors of poor outcomes, but very few have assessed the effects of treatment interruptions on treatment outcomes for MDR tuberculosis. METHODS We conducted a retrospective analysis among patients with MDR tuberculosis en...

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BACKGROUND The reasons that patients with multidrug-resistant tuberculosis (MDR TB) miss treatment are multi-factorial and complex. Identifying patterns of treatment interruption that predict poor outcomes can be used to target program activities aiming to improve treatment adherence. OBJECTIVE To characterize patterns of treatment interruption among MDR TB patients and determine the associat...

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INTRODUCTION Between January 1999 and December 2000, 125 patients in Lima, Peru were enrolled in individualized treatment for multidrug-resistant tuberculosis (MDR-TB). Hypokalemia was observed to be an important adverse effect encountered in this cohort. OBJECTIVE To identify risk factors associated with the development and persistence of hypokalemia during MDR-TB therapy, and to review the ...

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After decades of relatively little attention, the field of tuberculosis (TB) research has drawn much attention in recent years. New anti-TB drugs, those already commercially available and others still in the development pipeline, are among the primary drivers of active research, along with commitments from governmental and non-governmental entities for the global eradication of TB. However, man...

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ژورنال

عنوان ژورنال: Journal of Infectious Diseases

سال: 2014

ISSN: 0022-1899,1537-6613

DOI: 10.1093/infdis/jiu551